NIPT + Scan
Non-Invasive Prenatal Testing (9-40 Weeks)
- Analyses cell-free DNA in maternal blood
- Determines probability of Down's Syndrome
- Gender confirmation upon request
The NHS offers combined testing for Down’s syndrome (Trisomy 21), Edward’s syndrome (Trisomy 18) and Patau’s syndrome (Trisomy 13) at 10-14 weeks. If you are considering this testing, or have already had it – then stats indicate that 1 in 30 women may receive a high-risk result.
If you have fallen into the high-risk category it’s possible that you have been advised that you should have an amniocentesis or chorionic villus biopsy (CVS) to assess your baby’s chromosome pattern. The possibility of miscarriage from this test is approximately 1%.
For this reason, NIPT testing is becoming increasingly popular and it has the best detection rate of all screening tests; it estimates the risk of your baby having common chromosome conditions called a trisomy – the most common of which are Trisomy 13, 18 and 21. The detection rate is more than 99% accurate.
Whilst NIPT testing is not classed as a diagnostic test like amniocentesis or chorionic villus biopsy (CVS), it carries no risk of miscarriage and is therefore safe for your pregnancy, whilst providing the highest degree of accuracy. NIPT testing provides parents with peace of mind and allows them to make the appropriate decisions where further testing might be required.
Your sonographer or a trained phlebotomist will take a sample of venous maternal blood from the mother’s arm and the NIPT is combined with an ultrasound scan to confirm pregnancy. NIPT detects cell-free fetal DNA (cfDNA) in the mother’s bloodstream using next-generation sequencing technology, coupled with advanced bioinformatics analysis.
NIPT testing is also able to provide an optional analysis of the X and Y sex chromosomes, thus providing accurate gender confirmation. The accuracy of gender determination using NIPT is greater than 98%, but we always advise having the gender checked at your 20-week ultrasound anatomy scan in addition.
For most women, results will return as ‘low risk’ meaning it is very unlikely that the baby has one of these trisomy conditions, although they cannot all be ruled out as there is a very small risk that not all trisomy foetuses will be detected.
A ‘high risk’ result is indicative of a very high chance of your pregnancy being affected by a trisomy condition, although it does not definitely mean your baby will be affected. Overall the test identifies more than 99% of T21, T18 and T13 pregnancies. If you do receive a positive result, an amniocentesis or CVS screening test is generally advised to confirm the result.
*The Harmony™ NIPT test can be carried out from 10 weeks. The Harmony™ test can be used in singleton, twin, and egg-donor pregnancies and has been validated for use in pregnant women aged 18 to 48. Clinicians have used Harmony™ to screen over one million pregnancies in more than 100 countries around the world.
The price is the same if you request the additional option of including Harmony™ with foetal sex and / or the sex chromosome aneuploidy panel. Turn-around time is approximately 3-5 business days in most cases.
*The Panorama™ NIPT test can be carried out from as early as 9 weeks and is the most ordered NIPT, trusted in more than 3 million pregnancies. This simple blood test can assess conditions that can affect your baby’s health. Panorama™ offers prenatal screening for twin, egg donor, and gestational carrier pregnancies.
The price is the same if you request the additional option of including Panorama™ with foetal sex and / or the sex chromosome aneuploidy panel. Additional cost is applied when testing for the base panel (Trisomy 21,18 & 13) plus 22Q11.2 deletion syndrome (DiGeorge Syndrome or Velo-Cardio-Facial syndrome (VCFS)), or for base panel (Trisomy 21,18 & 13) plus 5 microdeletions. Panorama™ is also the only NIPT that tests for Triploidy. Turn-around time is approximately 7-10 business days in most cases.
Unsure about Panorama? Schedule your genetic information session here
*The IONA® NIPT test can be carried out from 10 weeks gestation. The IONA® test is a CE-IVD prenatal screening test which is offered to pregnant women to estimate the risk that their foetus may be affected with Autosomal Aneuploidies (AAs); Trisomy 21 (Down’s syndrome), Trisomy 18 (Edwards’ syndrome), Trisomy 13 (Patau’s syndrome), All additional trisomies (optional), All monosomies (optional). Sex Chromosome Aneuploidies (SCAs) (optional); 45,X (Turner syndrome), 47,XXX (Trisomy X), 47,XXY (Klinefelter syndrome), 47,XYY (Jacob’s syndrome), Fetal sex determination (optional).
Turn-around time is approximately 2-5 business days in most cases. IONA® offers prenatal screening for singleton, twin, egg donor, and gestational carrier pregnancies.
NIFTY screens for the three most common trisomy conditions present at birth – Down Syndrome, Edwards Syndrome and Patau Syndrome, plus 22, 16 and 9. NIFTY has an accuracy rate of over 99% for detection of these conditions. It also offers optional testing for other genetic conditions such as deletion syndromes (DiGeorge Syndrome, Plus 83 further deletion/duplication syndromes) and sex chromosome aneuploidies (Turner Syndrome, Klinefelter Syndrome, XXX, XYY). It can also provide gender confirmation for those parents wanting to know.
Our team of sonographers are here to provide comprehensive guidance as to which test will be most suitable for you. All NIPT testing is offered alongside an ultrasound scan. If you wish to book please contact us on 0207 1000 744 and we will be happy to help.