Julaine™ of Sweden London

Juläine™ of Sweden is a collagen bio-activator. It contains poly-L-lactic acid, which prompts the skin to produce its own collagen over the weeks following treatment.

The treatment involves placing the product with a fine cannula rather than a needle, across the lower face, allowing it to be distributed evenly. Poly-L-lactic acid is a biocompatible material long used in medicine. Once placed in the skin it acts as a signal to the fibroblasts, the cells responsible for producing collagen. The product itself is gradually absorbed. What remains is the collagen the skin has made in response. Unlike dermal fillers, Julaine is not placed to fill a space or reshape the face. The change comes from rebuilt structure within the skin, and it develops gradually rather than appearing immediately.

Skin collagen peaks somewhere between twenty-five and thirty-four, then falls by roughly one per cent a year for the rest of your life. A biostimulator does not fill a line. It asks your own fibroblasts to make collagen again, which is why it suits people who would rather stay ahead of that decline than chase it.

How well poly-L-lactic acid rebuilds

Juläine is new, but the material it is built on is not. Poly-L-lactic acid has been injected into faces for more than twenty-five years, and the evidence behind it did not come from cosmetic work at all. Its first regulatory approval, granted by the FDA in August 2004, was for facial lipoatrophy in people with HIV, the severe and sometimes near-total loss of facial fat that older antiretroviral drugs could cause. Approval for cosmetic use did not follow until 2009.

That history matters, but the figures need reading carefully. In the VEGA study, fifty patients with HIV-related facial lipoatrophy, whose median facial fat thickness at the outset was zero, gained a mean 6.8mm of total cutaneous thickness, still measurable at ninety-six weeks. That is a large gain because there was a great deal to replace, and it is not the result a cosmetic patient should expect. What it establishes is the more basic point, and the one that does carry over: the material is absorbed, and collagen is laid down in its place.

Those trials used Sculptra, the original poly-L-lactic acid product, not Juläine, and we would not claim otherwise. What they establish is what the material itself can do. Juläine is a newer formulation of the same active ingredient, designed to be easier to place and far easier to live with afterwards.

What carries across to ordinary cosmetic use is more modest and better matched to it. A 2025 review in the Aesthetic Surgery Journal reports that ultrasound typically shows increased dermal thickness within twelve weeks of treatment, and that tissue staining confirms an increase in type I collagen, laid down in denser and better organised bundles than before. That is the change you are paying for, and it builds over months rather than appearing on the day.

Poly-L-lactic acid earned its evidence rebuilding faces that had lost almost everything. Age-related volume and collagen loss is a far gentler version of the same problem.

Other Biostimulator Treatments

Juléine is one of several biostimulator treatments we offer. We also provide Radiesse Hyperdilute and HArmonyCa, both based on calcium hydroxylapatite. Radiesse Hyperdilute is used to improve the quality and firmness of the neck and décolletage. HArmonyCa combines hyaluronic acid with calcium hydroxylapatite microspheres and is used in the mid and lower face. Your doctor will advise which approach suits your assessment.

Part of our pathways. Juläine is used in Menopause and Skin and in Weight Management and Skin Recovery.